ISC Intelligence in Science will organise the second edition of the UNGA76 Science Summit around the 76th United Nations General Assembly (UNGA76) in New York in September 2021. The objective of the virtual meeting will be to raise awareness of the role and contribution of science to the attainment of the United Nations Sustainable Development Goals (SDGs). It will highlight initiatives that provide models for global science mechanisms and activities in support of the SDGs, particularly in science infrastructure and capacity-building. Science will enable sustainable economic, environmental, and societal development. Science is more than a funding prioritization exercise: science is impacting all areas of policy-making and is playing a more critical role in how policy objectives are achieved and the consequent benefit to people everywhere, including responses to global challenges.